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The Genetic Architecture of Type 2 Diabetes by Professor Daniel DiCorpo, Boston University

Mon, October 30th, 2023
1:00 pm
- 1:50 pm

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Beyond Genome Wide Association Studies: The Genetic Architecture of Type 2 Diabetes, by Professor Daniel DiCorpo, Boston University School of Public Health, Monday October 30, 1:00 – 1:50pm, North Science Building 017, Wachenheim

 

Genome Wide Association Studies (GWAS) have identified hundreds of genetic associations with Type 2 Diabetes. However, challenges remain in utilizing these discoveries for biological applications and translational medicine. We show that genetic variants associated with increased diabetes risk may be clustered into groups representing likely disease sub-types. Subsequently, the clustered groups of variants show differential associations with diabetes outcomes, such as coronary artery disease and kidney function. These findings improve our understanding of the biological mechanisms of diabetes and may provide a template for more individualized genetic risk prediction. Another component of our efforts to understand the genetic basis of diabetes includes whole genome sequencing studies with an emphasis on diverse genetic ancestry samples. We show that inclusion of diverse genomic data leads to novel variant-disease associations and improved prioritization of likely causal variants for functional follow-up.

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